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Korean researchers find cancer undo button, turn tumor cells to normal ones

In a trailblazing advancement in cancer therapy, researchers at Korea Advanced Institute of Science and Technology (KAIST) have developed a technology that transforms colon cancer cells into normal-like cells without destroying them.

This innovative approach, led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, represents a significant departure from traditional cancer treatments that rely on killing cancer cells, often leading to severe side effects and risks of recurrence.

"The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon. This study proves that such reversion can be systematically induced," Cho remarked.

Rethinking cancer cell route

In the introduction to their paper, the researchers detail how research in acute myeloid leukemia, breast cancer, and hepatocellular carcinoma has shown that encouraging tumor cells to differentiate or trans-differentiate can achieve this reversal.

However, identifying the key regulators responsible for driving these processes remains a challenge. If these regulators from normal cell differentiation can be pinpointed and applied to cancerous ones, they could offer a promising alternative to current cancer treatments.

Conventional cancer treatments focus on eradicating cancer cells. While effective in many cases, this method faces two critical challenges: the potential for cancer cells to develop resistance and return, and the collateral damage to healthy cells, resulting in debilitating side effects.

The KAIST team has taken a radically different approach by targeting the root causes of cancer development. Their research hinges on the idea that cancer cells, during their transformation from normal cells, regress along the differentiation trajectory—the process by which normal cells mature into specific functional types.

To tackle this, the researchers created a digital twin of the gene network involved in the differentiation trajectory of normal cells. This computational model allowed them to simulate and analyze the intricate gene interactions that regulate cell differentiation.

Through their simulations, the team pinpointed master molecular switches capable of steering cells from colon cancer back into a normal-like state. These findings were then validated through molecular experiments, cellular studies, and animal trials, demonstrating the effectiveness of this approach.

Toward reversible cancer therapy

The implications of this research are profound. By shifting the focus from destroying cancer cells to reverting them, this technology could lead to the formulation of a new class of cancer treatments.

Such therapies could potentially minimize side effects and reduce the likelihood of recurrence, addressing some of the most pressing challenges in oncology.

Cho elaborated, "This research introduces the novel concept of reversible cancer therapy by reverting cancer to normal cells. It also develops foundational technology for identifying targets for cancer reversion through the systematic analysis of normal cell differentiation trajectories."

While the study focused on colon cancer, the underlying principles could be extended to other cancer types. By applying the digital twin technology to various cancer gene networks, researchers hope to identify similar molecular switches in different contexts, paving the way for broadly applicable, reversible cancer therapies.

This innovative approach marks a paradigm shift in cancer treatment. By targeting the genetic mechanisms underlying cell transformation, researchers have provided a roadmap for safer and potentially more effective therapies. As the technology develops, it may redefine how we combat cancer, offering new hope to patients worldwide.

The study has been published in the journal Advanced Science.

https://www.yahoo.com/news/korean-researchers-cancer-undo-button-125658079.html



These guys may have just unlocked the door to a whole new type of medicine, maybe even the cure for some or all cancers. Medical advancements seem to be coming at a good clip lately. AI being used is part of it, but these guys went completely outside the box to work the problem within IMO. KUDOS. Hopefully they can refine it in time for me and my fellow cancer fighting friends.

I just watched a You Tube video on a new treatment for Diabetes that is simply amazing. They mentioned some almost miraculous cancer treatments. (research) It is amazing how far we have come in medicine, and how far we progress every year.

*peeking up over the bottom of your computer screen* Well hurry it up I don't know how many years I got left.

I think it' not only wonderful that such advancements are being made but also in this case it's in a nation with very low healthcare and prescription medications costs compared to us. It helps defy the popular myth that our healthcare costs are so high to advance R&D.

No it doesn't. The State covers the cost of health care but that means they take the money from the citizens. Healthcare R&D is expensive, it gets paid, either by individuals or the State.

5%. They pay 5%. And factually the total cost of their healthcare is much lower per person.

It seems this myth continues.

Why do American feel it makes sense to not only pay for their R&D but then pay the highest prices on the planet for the drugs they create from that R&D we ourselves paid for? So your assertion seems to be that we finance their ability to get rich on the drugs we pay for them to develop. Hmmmm.....

South Korea spends pennies on the dollar in costs to America, pay much less for prescription drugs and they seem to be developing drugs just fine. As my grandpa used to say, "The proof is in the pudding".

And I suppose you expect me to just take your word?

And who pays 5% of what?

I talk to people from other countries every day in forums on pancreatitis, whipple surgery, colon cancer, pancreatic cancer.. While they all love the cost of their coverage they also all complain that thy have to wait forever to get anything done. Got agressive pancreatic cancer and need an ERCP or MRI tuff crap we can get you in for your test in 3 to 6 months..... hell they could be dead before they ever get a test. Both our form of Health insurance, and theirs have their pro's and their cons. I see it every day.

Healthcare System in Korea

How much does health insurance cost in South Korea?
If you are employed, 5% of your income will go towards the NHI. The amount self-employed expats pay is based on their income. On average, most monthly healthcare costs average around 120,000 KRW (100 USD) per month.

https://www.hira.or.kr/dummy.do?pgmid=HIRAJ010000006000

What country has the most expensive prescription drugs?
Prescription drug prices in the United States are significantly higher than in other nations, with prices in the United States averaging 2.78 times those seen in 33 other nations, according to a new RAND report.Feb 1, 2024

https://www.rand.org/news/press/2024/02/01.html

And I still doubt you believe it.

I actually don't doubt that all healthcare systems have their problems. I think the biggest issue is that we pay far more than any other country not only in healthcare costs and procedures but in prescription drug costs and according to the rankings we're not close to the best. I certainly don't see any rational excuse why our country should be paying double, or almost double for prescription drugs than everyone else on the planet.

At least you gave some reference, though you first link is about self employed people and you believe that defends your original assertion?

Try reading it again......



Two different groups of people. The first are all who are employed. The second group are the self employed "expats".

Actually the much lower amount people pay for prescription drug costs around the globe while R&D and new drugs are created and manufactured there does that. Somehow it seems they depend more on making money on the new drugs they create than having their people pay for that R&D and the highest prescription drug costs in the plant as well.

This is too political for here.

We hadn't mentioned anything about politics though I feel you may be right. That's the biggest reason the status quo in our healthcare remains the way it is. I don't actually feel the need or desire to start a new thread about it in the political forum but if you do that would make more sense than continuing the conversation here.

This is great news. I hope they continue to research and develop this new technology to help people with this insidious disease. I lost my wife 3 years ago to cancer and saw what she went through and saw many others with it. Again great news 👍

I can only speak for my own. My wife has had fatigue issues for a couple of years now. They finally did a scan in early summer and found spots on her liver and ovaries. It took until early December for a follow-up MRI, and we are still awaiting results from that.

I’m like, why do we pay high taxes in Canada when the health care sucks so tremendously?

Lack of competition?

X2